A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Patel, Chirag A.
- Nanomedicine:Emerging Field in Medicine
Authors
1 Department of Pharmaceutics, S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-Gozaria Highway, Kherva-382711, Ta. & Dist: Mehsana (N.G.), IN
2 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Mehsana-384001, Gujarat, IN
3 Sarswati School of Pharmacy Ranela, At-Ranela, Dist.-Becharaji, IN
Source
Research Journal of Science and Technology, Vol 2, No 3 (2010), Pagination: 41-46Abstract
Nanomedicine is beginning to emerge from research in nanotechnology. Nanotechnologies have features on the scale of nanometers or billionths of a meter. In biology the scale of a single human hair is about 80,000 nanometers wide and a red blood cell is about 7,000 nanometers wide. Materials can be produced that are Nanoscale in one dimension (such as ultra-thin surface coatings), in two dimensions (for example, nanotubes and nanowires), or in all three dimensions (nanoparticles and Buckyballs). Nanoscale materials often have novel properties related to their high ratio of surface area and quantum effects.Keywords
Nanomedicene.- Enhancement of Solubility of Poorly Water Soluble Drug (Allopurinol) Through Solid Dispersion
Authors
1 Department of Pharmaceutics, S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana- Gozaria Highway, Kherva-382711, Ta. and Dist: Mehsana (N.G.), IN
2 Department of Pharmaceutics, S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-Gozaria Highway, Kherva-382711, Ta. and Dist: Mehsana (N.G.), IN
3 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Mehsana-384001, Gujarat, IN
4 Department of Pharmaceutics, Nootan Pharmacy College, Visnagar-384315, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 156-163Abstract
The present study is to enhance the solubility of poorly water soluble drug by using different techniques like solid dispersion and crystal formation and selected drug was allopurinol. Allopurinol is poorly water soluble drug (which has solubility 0.1mg/ml) used in treatment of gout. Rapid onset of action of allopurinol drug in treatment of gout is required. Solubility is rate limiting step for this drug. So, by enhancing the solubility we can improve the bioavailability of poorly water soluble drug. For solubility enhancement we used different polymer like PEG4000, PVPK30, poloxamer 127 grade in solid dispersion. And in crystal formation used the different 11 solvent among them only ethanol, ether, and (dimethyl sulfoxide) DMSO has found good solubility and dissolution rate. For selection of solvent and polymer we had checked the compatibility by using (Differential Scanning Colorimeter) DSC And (Infra Red Spectroscopy) IR, and proved that used solvent which compatible with drug. For preparation of solid dispersion we were used melting method and solvent evaporation method. And then prepared solid dispersion carried out for scanning electron microscope) SEM study for surface property of solid dispersion. Checked the solubility and disintegrating time. Final formulation was prepared tablet dosage form after optimized batch of solid dispersion and take dissolution of tablet. All tablet prepared from solid dispersion, crystal and marketed were compare by dissolution study .and finally concluded the tablet prepared by solid dispersion is best than others.